Antidiabetic and Toxicity Studies of Some Novel Oxazolone Derivatives

In this research work, 2, 4-substituted oxazolone derivatives OXZ-1 to OXZ-5 were screened for antidiabetic activity at 200 and 400 mg/kg b.w. p.o. for 15 days in streptozotocin induced diabetic rats. Acute and sub-acute toxicity studies were performed as per OECD guideline Up and Down Procedure425 and 407. Clinical signs, body weight, hematological, biochemical and histopathological examinations were carried out in sub-acute toxicity studies. The compounds OXZ-1, OXZ-3 & OXZ-5 at 400 mg/kg p.o reduced fasting blood glucose levels in streptozotocin induced diabetic rat on 15th day. In acute toxicity study no lethality was found up to 5000 mg/kg p.o. Sub-acute toxicity study revealed the elevated level of AST and ALT. The toxic signs in liver and kidney were appeared in histopathological studies at 1000 mg/kg p.o. of OXZ-1. It was concluded that the studied derivatives possess significant antidiabetic activity with mild toxicity in liver and kidney.